Thursday, April 23, 2009

Test for Steroids Shows 'Filly' a Male

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Year-and-a-half-old testing for anabolic steroids in racehorses produced some unusual results — including the discovery of a Standardbred filly that’s actually a male.

In Pennsylvania, tests showed a high elevation of testosterone in Arizona Helen, who was raced at the harness track Harrah’s Chester Racetrack and Casino, officials said April 23 during a session at the Association of Racing Commissioners International annual convention in Lexington. The test led to further tests that showed Arizona Helen’s white blood cells indicated she had the “XY sex reversal.”

Arizona Helen is an equine hermaphrodite, one of about 12 “sex-reversed” female horses.

“A few little curve balls have been thrown our way,” said Dr. Scot Waterman, executive director of the Racing Medication and Testing Consortium.

Kent Hastings of the United States Trotting Association said it was found that Arizona Helen has a vagina as well as testicular tissue. Arizona Helen is allowed to race as a male, and isn’t suited for breeding purposes.

Testing for anabolic steroids also has uncovered geldings that produce testosterone, Waterman said. The positives required “challenge tests” to prove the geldings have tissue-producing testosterone found in intact males.

Unusual discoveries aside, the RMTC has completed its work on plasma studies for the four regulated steroids — stanozolol, testosterone, boldenone, and nandrolone — Waterman said. There are four options to set threshold levels for testing: set a desired withdrawal period and work backwards; set an arbitrary threshold; use limits determined by quantification of the substances in plasma; or determine where the pharmacologic impact of the drugs end.

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